- Sabathia, C.C.
- Sabatini, Gabriela
- Sabbatini, Rory
- Sacco, Joe
- Sadler, Donnie
- Saenz, Olmedo
- Safin, Marat
- Sakic, Joe
- Salazar, Roger
- Sales, Nykesha
- Salmon, Tim
- Salo, Sami
- Salo, Tommy
- Salvador, Bryce
- Samardzija, Jeff
- Sampras, Pete
- Samsonov, Sergei
- Samuel, Asante
- Samuel, Khari
- Samuels, Chris
- Samuelsson, Mikael
- Sanchez, Javier
- Sanchez, Jesus
- Sanchez, Rey
- Sanders, Chris
- Sanders, Deion
- Sanders, Doug
- Sanders, Frank
- Sanders, Jeff
- Sanders, Lewis
- Sanders, Reggie
- Sanderson, Geoff
- Sands, Mike
- Santana, Johan
- Santana, Manuel
- Santiago, Benito
- Santiago, Daniel
- Santiago, Jose
- Santo, Ron
- Sapp, Warren
- Saprykin, Oleg
- Sarich, Cory
- Sasaki, Kazuhiro
- Satan, Miroslav
- Saturday, Jeff
- Sauerbeck, Scott
- Sauerbrun, Todd
- Sauter, Cory
- Savage, Brian
- Savard, Marc
- Sayers, Gale
- Scalabrine, Brian
- Scatchard, Dave
- Schalk, Ray
- Schilling, Curt
- Schlesinger, Cory
- Schmidt, Jason
- Schmidt, Joe
- Schmidt, Mike
- Schneider, Brian
- Schneider, Mathieu
- Schnellenberger, Howard
- Schnyder, Patty
- Schoenweis, Scott
- Schrempf, Detlef
- Schroeder, Bill
- Schroeder, John
- Schulters, Lance
- Schulz, Kurt
- Scott, Chad
- Scott, Darnay
- Scott, Lynn
- Scott, Sean
- Scott, Steve
- Scott, Travis
- Seabrook, Brent
- Searcy, Leon
- Seau, Junior
- Seaver, Tom
- Sedin, Daniel
- Sedin, Henrik
- Sefolosha, Thabo
- Segares, Gonzalo
- Segui, David
- Sehorn, Jason
- Seiple, Larry
- Selanne, Teemu
- Sele, Aaron
- Seles, Monica
- Sellers, Mike
- Selmon, Lee Roy
- Serrano, Antonio
- Servais, Scott
- Seubert, Rich
- Sewell, Joe
- Sexon, Richie
- Shade, Sam
- Shanahan, Brendan
- Shannon, Randy
- Sharapova, Maria
- Sharp, Patrick
- Sharpe, Shannon
- Sharper, Darren
- Sharper, Jamie
- Shaw, Bobby
- Shaw, Brian
- Shaw, Jeff
- Shaw, Terrance
- Shaw, Tom
- Shea, Aaron
- Sheehan, Patty
- Sheets, Ben
- Sheffield, Gary
- Sheldon, Mike
- Shell, Art
- Shelley, Jody
- Shelton, Daimon
- Shields, Paul
- Shields, Scot
- Shields, Will
- Shipp, Marcel
- Shockey, Jeremy
- Short, Brandon
- Shula, Don
- Sidney, Dainon
- Siedlecki, Jack
- Sierra, Ruben
- Sigel, Jay
- Sillinger, Mike
- Simmons, Al
- Simmons, Anthony
- Simmons, Bobby
- Simmons, Brian
- Simmons, Cedric
- Simmons, Clyde
- Simon, Chris
- Simon, Corey
- Simon, Randall
- Simoneau, Mark
- Simpson, Mark
- Simpson, O J
- Simpson, O.J.
- Simpson, Scott
- Simpson, Todd
- Sims, Barry
- Sinceno, Kaseem
- Sinclair, Michael
- Sindelar, Joey
- Singh, Vijay
- Singletary, Mike
- Singleton, Chris
- Siragusa, Tony
- Sisco, Andrew
- Sisk, Geoffrey
- Sisler, George
- Skinner, Brian
- Skrastins, Karlis
- Slade, Chris
- Slater, Jackie
- Slater, Kelly
- Slaughter, Chad
- Slaughter, Enos
- Sloan, David
- Sluman, Jeff
- Small, Torrance
- Smith, Aaron
- Smith, Akili
- Smith, Antowain
- Smith, Ben
- Smith, Brent
- Smith, Brian
- Smith, Bruce
- Smith, Chris
- Smith, Chuck
- Smith, Darrin
- Smith, Dave
- Smith, David
- Smith, Dick
- Smith, Emmitt
- Smith, Frankie
- Smith, Herb
- Smith, Hunter
- Smith, Jackie
- Smith, Jason
- Smith, Jeff
- Smith, Jermaine
- Smith, Jim
- Smith, Jimmy
- Smith, Kent
- Smith, Kevin
- Smith, Lamar
- Smith, Larry
- Smith, Lovie
- Smith, Marvel
- Smith, Maurice
- Smith, Michael
- Smith, Mike
- Smith, Otis
- Smith, Phil
- Smith, Roy
- Smith, Stan
- Smith, Steve
- Smith, Taylor
- Smith, Terrelle
- Smith, Thomas
- Smith, Walter
- Smith, Wes
- Smith, Wyatt
- Smolinski, Bryan
- Smyth, Ryan
- Snider, Duke
- Snow, Eric
- Snow, Garth
- Snyder, Dan
- Snyder, John
- Sojo, Luis
- Sopel, Brent
- Sorensen, Nick
- Sorenstam, Annika
- Soriano, Alfonso
- Sosa, Sammy
- Soto, Geovany
- Soumare, Bakary
- Souray, Sheldon
- Sowell, Jerald
- Spacek, Jaroslav
- Spahn, Warren
- Sparks, Steve
- Speaker, Tris
- Spears, Marcus
- Spencer, Jimmy
- Spencer, John
- Spencer, Shane
- Speraw, Kirk
- Spicer, Paul
- Spiezio, Scott
- Spikes, Cameron
- Spikes, Takeo
- Spires, Greg
- Spivey, Junior
- Sprewell, Latrell
- Springer, Mike
- Springs, Shawn
- Stack, Mike
- Stackhouse, Jerry
- Stadler, Craig
- Stairs, Matt
- Staley, Duce
- Stankowski, Paul
- Stanley, Chad
- Stanton, Mike
- Stargell, Willie
- Starks, Duane
- Starks, John
- Starr, Bart
- Staubach, Roger
- Stecker, Aaron
- Stein, Blake
- Steinberg, Jeff
- Steinbrenner, Hank
- Stenerud, Jan
- Stengel, Casey
- Stepania, Vladimir
- Stephenson, Dwight
- Steussie, Todd
- Stevens, Kevin
- Stevens, Lee
- Stevens, Matt
- Stevens, Scott
- Stevenson, Eric
- Stewart, Kordell
- Stewart, Matt
- Stewart, Michael
- Stewart, Ray
- Stewart, Scott
- Stewart, Shannon
- Stewart, Tony
- Stillman, Cory
- Stills, Gary
- Stinnett, Kelly
- Stockton, Dave
- Stockton, John
- Stokley, Brandon
- Stone, John
- Storr, Jamie
- Stoudamire, Amare
- Stoudamire, Damon
- Stover, Matt
- Strahan, Michael
- Straka, Martin
- Strange, Curtis
- Streck, Ron
- Streets, Tai
- Stricker, Steve
- Strickland, Mark
- Strickland, Rod
- Strickland, Scott
- Stringer, Korey
- Strong, Mack
- Strother, Ann
- Strudwick, Jason
- Stuart, Brad
- Stubblefield, Dana
- Stupples, Karen
- Sturm, Marco
- Sturtze, Tanyon
- Stydahar, Joe
- Stynes, Chris
- Sullivan, Chip
- Sullivan, Chris
- Sullivan, Mike
- Sullivan, Scott
- Sullivan, Steve
- Sullivan, Tom
- Summerhays, Bruce
- Sundin, Mats
- Suppan, Jeff
- Sura, Bob
- Surhoff, B.J.
- Surtain, Patrick
- Sutherland, David
- Sutherland, Kevin
- Sutherland, Vinny
- Sutton, Andy
- Sutton, Don
- Sutton, Hal
- Suzuki, Ichiro
- Suzuki, Mac
- Swann, Lynn
- Swayne, Harry
- Sweeney, Matt
- Sweeney, Mike
- Swift, Stromile
- Swindell, Greg
- Swisher, Nick
- Sydor, Darryl
- Sykora, Petr
- Szczerbiak, Wally